Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD subjects (...) completed a neuropsychological battery to assess cognition and the SAPS to examine psychosis. Correlational analyses assessed associations between hallucinations and delusions with cognitive domains. RESULTS: 48 subjects reported psychotic symptoms: 25 experienced hallucinations without delusions, 23 had symptoms dominated by delusions. Severity and/or number of hallucination subtypes were significantly correlated with lower scores in language, memory, attention, executive functioning, and visuospatial ability. Correlations with delusions were non-significant. Tests of differences in the size of the correlations between groups revealed a significant relationship between language and visuospatial performance with hallucinations. CONCLUSIONS: Cognitive correlates of hallucinations and delusions appear to be different in PD, suggesting distinct pathogenic mechanisms and possibly anatomical substrates. Hence, delusions may not share the same associations with dementia as hallucinations. Since this is a new finding, further studies will be needed to confirm our results. (shrink)

That all pleasure is good and all pain bad in itself is an eternally true ethical principle. The common claim that some pleasure is not good, or some pain not bad, is mistaken. Strict particularism (ethical decisions must be made case by case; there are no sound universal normative principles) and relativism (all good and bad are relative to society) are among the ethical theories we may refute through an appeal to pleasure and pain. Daniel Dennett, Philippa Foot, R M (...) Hare, Gilbert Harman, Immanuel Kant, J. L. Mackie, and Jean-Paul Sartre are among the many philosophers addressed. (shrink)

If nowadays categories seems to cover a multitude of different enquiries, we can see some continuity and coherence among them, and we can get some sense of what the subject is, by going back to the first treatise to receive the name, the Categories of Aristotle. The scheme of categories worked out by Aristotle in that book was used by him in subsequent works to solve a variety of problems. On one plausible hypothesis, Aristotle’s scheme was partly shaped by ontological (...) considerations. However, one can construct categorial schemes that are free of ontological assumptions, and I call such schemes and the principles on which they are constructed “pure.” A purified Aristotelian scheme is one of a multiplicity of categorial schemes that can be generated by a sufficiently general pure categorial principle. In the penultimate section of this paper I consider a useful scheme, generated in this way, that categorizes the elements of our discourse about discourse. This links up with J. L. Austin’s discussion of the nature of illocutionary acts and throws light on the interconnections between such problematic notions as sentence, meaning, and proposition. (shrink)

Ce texte constitue le chapitre 12 du livre de J. S. Goldstein, Long Cycles : Prosperity and War in the Modern Age, New Haven, Yale University Press, 1988. L'ensemble du livre est accessible ici. - Économie et Marxisme – Nouvel article.

Ethical antirealists believe the words ‘good’ and ‘bad’, and ‘right’ and ‘wrong’, do not signify properties that objects and actions have or might have. They believe that when a person calls pain or any other event ‘bad’ and adultery or any other action ‘wrong’, he does not report some fact about that object or action. J. L. Mackie defends ethical anti-realism in part by appealing to an ontological queerness he believes value properties would have if they existed. "If there were (...) objective values," Mackie writes, "they would be entities or qualities or relations of a very strange sort, utterly different from anything else in the universe." Goodness would have a queer magnetic power. "Something's being good both tells the person who knows this to pursue it and makes him pursue it. An objective good would be sought by anyone who was acquainted with it, not because of any contingent fact that this person, or every person, is so constituted that he desires this end, but just because the end has to-be-pursuedness somehow built into it," Mackie says. If there were a property of the sort we conceive of good as being, it would be a queer property—one we cannot reasonably believe exists, Mackie argues. (shrink)

1. L'aspect le plus important du toucher est sa relation au temps et à l'étendue, relation constituée par le mouvement même du toucher. En référence aux conceptions de E. Straus, on expose la distinction entre le toucher et l'être-touché à la lumière d'expériences faites par nous avec des animaux. 2. Le toucher est un être-dans-les-limites-propres et en même temps un franchissement de ces limites, être par lequel l'objet touché est éprouvé à la fois comme „Gegenstand” et comme „Mitseiend”. „Pour le (...) tactile, c'est l'être à deux qui se place au premier rang.” L'affirmation de l'être par le sens du toucher est saisissante dans le cas du se-touchersoi-même, qui est une union exceptionnelle d'activité et de passivité. 3. La reconnaissance tactile de la forme présente elle aussi une dialectique d'activité et de passivité, dialectique qui procède sous la forme d'un développement surmontant le temps, et cela à partir d'un schéma produit dans l'acte même de préhension. On renvoie aux études de V. von Weizsäcker sur le „Gestaltkreis”. Il faut se rappeler aussi l'inquiétude primaire de la main, qui dans le jeu de la main avec un objet devient perdurante. 4. La main peut enserrer un objet. En ce faisant une image schématique tactile est donnée, image qui fonctionne comme hypothèse ou comme principe organisateur du développement prolèptique de l'exploration tactile ultérieure. L'analyse phénoménologique du toucher avec la main se révèle comme une préfiguration de la pensée par jugements synthétiques. Il est donc vrai, comme le remarquait Herder et comme le confirmaient Goldstein et Merleau-Ponty, que la perception telle que l'homme l'effectue et l'existence spirituelle sont identiques. 5. En se référant aux recherches de Révèsz et de Palagyi, on analyse le caractère propre du monde tactil. L'exploration tactile procède selon un véritable développement, donnant lieu à des déterminations anticipatives et rétrospectives qui assurent la continuité de l'événement et de son sens. La perception tactile permet de décrire l'unité continue des phases discontinues objectivement constatables, „comme si” attente et souvenir, jugements provisoires et vérification, fixations conceptuelles et corrections étaient mises en œuvre. 6. Important est l'aspect affectif et émotif des impressions tactiles et leur rapport aux relations interhumaines. 7. Par le toucher l'homme se trouve d'une manière „sensible” en relation personnelle avec cette matérialité des choses qui demeure cachée aux sens-à-distance. Cette participation a un double aspect. Elle est comme le surgissement d'un „état d'âme”, une '‚Befindlichkeit”, mais en même temps elle est le point de départ actif d'un sentir, d'un „comprendre”, d'un „saisir par le dedans”, d'un être-ému, d'un être-frappé par l'objet touché qui se rend présent comme un „quale” propre, comme une matière, comme un être-en-soi. On rappelle le caractère propre du caresser, par lequel l'„être à deux” de l'objet caressé devient complémentaire avec celui du caressant actif. Les concepts usuels par le moyen desquels, dans la vie pratiquement et gnostiquement vécue, sont indiquées les qualités tactiles les plus importantes, ont comme but de nous référer aux propriétés des choses qui prennent place dans le monde géométrique et dans l'espace objectivement mesurable et qui fondent notre orientation naturelle. On rappelle les recherches de von Homborstel au sujet des propriétés internodales des impressions tactiles. Celles-ci nous montrent comment un „savoir” qui accompagne ta perception peut changer une impression sensible. La relation affective, déterminée par un „savoir” nuancé et par un système de valeurs, change la réalité tangible, la substantialité du corps, de la „chair”. Ce changement affectif de la matière, cette „transsubstantiation phénoménale” peut se réaliser facilement par rapport à des objets dont nous savons qu'ils appartiennent ou ont appartenu à quelqu'un. La signification qu'a une chose change la matière de l'objet, objet qui, précisément par le toucher, se rend présent „en chair et en os”. On illustre ceci avec plus de précision grâce aux phénomènes du fétichisme et grâce à de simples expériences de la vie courante. Si nous cherchons un point de vue anthropologique à partir duquel le toucher, dont la main réalise les possibilités, peut prendre un sens, une approche d'un tel point de vue devra s'effectuer à partir de la certitude non-représentable que l'unité ontique de la nature et de l'esprit est dans l'homme la réalité d'une participation possible, participation qui, dans notre existence, n'est qu'indiquée. L'„inquiétude” de la main jamais remplie et toujours chercheuse que nous avons remarquée, est le signe humain de notre existence concrète. Ainsi le toucher nous montre ce que Valéry remarquait à propos de l'esprit : „L'esprit est à la merci du corps, comme les aveugles sont à la merci des voyants.”. (shrink)

Late Babylonian astronomical texts contain records of the stationary points of the outer planets using three different notational formats: Type S where the position is given relative to a Normal Star and whether it is an eastern or western station is noted, Type I which is similar to Type S except that the Normal Star is replaced by a reference to a zodiacal sign, and Type Z the position is given by reference to a zodiacal sign, but no indication of (...) whether the station is an eastern or western station is included. In these records, the date of the station is sometimes preceded by the terms in and/or EN. We have created a database of station records in order to determine whether there was any pattern in the use of these notation types over time or an association with any bias in the station date or the type of text the station was recorded in. Predictive texts, which include Almanacs and Normal Star Almanacs, almost always use Type Z notation, while the Diaries, compilations, and Goal-Year Texts use all three types. Type Z records almost never include in or EN, while other types seem to include these interchangeably. When compared with modern computed station dates, the records show bias toward earlier dates, suggesting that the Babylonians were observing dates when the planets appeared to stop moving rather than the true station. Overlapping reports, where a station on the same date was recorded in two or more texts, suggest that predicted station dates were used to guide observations, and that the planet’s position on the predicted stationary date was the true point of the observation rather than the specific date of the stationary point. (shrink)

In Wrong Medicine, Lawrence J. Schneiderman, M.D., and Nancy S. Jecker, Ph.D., address issues that have occupied the media and the courts since the time of Karen Ann Quinlan. The authors examine the ethics of cases in which medical treatment is offered--or mandated--even if a patient lacks the capacity to appreciate its benefit or if the treatment will still leave a patient totally dependent on intensive medical care. In exploring these timely issues Schneiderman and Jecker reexamine the doctor-patient relationship and (...) call for a restoration of common sense and reality to what we expect from medicine. They discuss economic, historical, and demographic factors that affect medical care and offer clear definitions of what constitutes futile medical treatment. And they address such topics as the limits on unwanted treatment, the shift from the "Age of Physician Paternalism" to the "Age of Patient Autonomy," health care rationing, and the adoption of new ethical standards. (shrink)

O livro almeja ser representativo nos principais debates contemporâneos, oferecendo uma visão panorâmica sobre o campo na atualidade e permitindo-se aprofundar em algumas discussões selecionadas.O ambiente não pode ser reduzido ao “meio ambiente”, à natureza não humana. Ele não é meramente algo que “nos envolve”, um envoltório: o ambiente somos também nós, seres humanos, histórica e culturalmente situados. Quanto aos territórios, eles se estabelecem em íntima conexão com os ambientes em suas dimensões paisagística e material, quer sejam os processos geoecológicos, (...) quer sejam as formas e as dinâmicas socialmente produzidas. Analisar os territórios significa examinar como, a cada momento, os ambientes, seus recursos e significados são disputados e viram objeto de conflitos.O público-alvo principal são os estudantes dos últimos anos da graduação, além daqueles em nível de pós-graduação, de todas as áreas que lidam com problemas e conflitos ambientais. Afora os pesquisadores iniciantes e os jovens universitários em geral, porém, podemos presumir que profissionais experientes também poderão tirar proveito do material de diversos capítulos. É razoável, por fim, nutrir a expectativa de que muito do que este livro contém possa (retro)alimentar o ativismo ambiental crítico e a prática de combater as iniquidades e as distorções que se acumulam em nossas sociedades, principalmente as muitas situações de flagrante injustiça ambiental. (shrink)

Professional skepticism is a critical component of the auditor’s skill set. Developing this component takes time for accounting students and new auditors. Rather than waiting until they have an internship or a full-time auditing position, students can begin practicing this essential skill earlier in their academic careers. The case presents students in their first undergraduate auditing course an introduction to the need for more complex thinking and professional skepticism in the auditing and forensic accounting areas. The case focuses on risk (...) assessment and critical evaluation of audit evidence, primarily through audit interviews. In addition, the case allows students to learn the value of preparation and strategy uniquely: their first attempt at the case is almost impossible to solve. (shrink)

Wemay look at the relation of will and motive from another side as follows: Will, we have said, is an individual response to an individual situation. Like the situation itself, it is not a fixed thing persisting through change, but involved in a continuous flow of change, re-adapting itself constantly in one respect or another to recognized changes of circumstance. It can have no more immutability than circumstance, and if it is not to be left behind in the march of (...) events and become old-fashioned, it should have the capacity for the same rapidity of change. Now motives also change, but in a different way. First one motive operates, then another, as circum-. (shrink)

In this paper the analysis of the classical dynamics of a charged particle is carried out without considering that the electromagnetic field necessarily goes to zero at infinity. A quite general non-linear equation of motion is obtained for an extended charged particle valid for any distribution of charge in the particle and for an electromagnetic field satisfying any boundary conditions. Some common approximations are analyzed with detail to determine how the usual difficulties arise.

This article concerns a phenomenon of elementary quantum mechanics that is quite counter-intuitive, very non-classical, and apparently not widely known: a quantum particle can get reflected at a potential step downwards. In contrast, classical particles get reflected only at upward steps. As a consequence, a quantum particle can be trapped for a long time (though not forever) in a region surrounded by downward potential steps, that is, on a plateau. Said succinctly, a quantum particle tends not to fall off a (...) table. The conditions for this effect are that the wave length is much greater than the width of the potential step and the kinetic energy of the particle is much smaller than the depth of the potential step. We point out how the topic is accessible with elementary methods, but also with mathematical rigor and numerically. (shrink)